A new study from the National Institutes of Health has discovered a complex of genes that may make certain women susceptible to PMDD (Premenstrual Dysphoric Disorder) – one of the most severe forms of PMS. The women in the study who suffered from PMDD had a gene that reacted differently when exposed to hormones like estrogen and progesterone and was thus defenseless against the typical PMS syndromes of depression, anxiety, irritability and mood swings. Overall, the study connected PMDD with the biological functioning of the body and established an intrinsic difference in the molecular and genetic apparatus of women suffering from the same.